So i ll give my thoughts for mid-game-play now: Collecting Heavenly chips, [Playstyle: ACTIVE playstyle, NO TOOLS (No Clickbots, extensions, helpers, cheats etc.)]
I only unlock the "One mind" upgrade, which starts the Grandmapocalypse, but I dont research on (so, i dont research on "exotic nuts") This lets me have golden cookies and wrinklers at the same time: "One mind" -> Grandmatriarch status is "Awoken" -> Chance for Wrath/Red cookie is 33%. The origin chance of frenzy (*7) in a golden cookie is 47,858%, with the 33% chance of a red cookie (wherin frenzy does not appear) it drops to 31,586%. if u consider that golden/red cookies "overlap" by about 20 seconds, u can say that u are fairly in frenzy one third of the (active) playtime, which also applies to your wrinklers: 6*7/3=14 times your basis Cps (*6 from wrinklers, *7 from frenzy, /3 because frenzy is active only ~1/3rd of the time)
I m working with all upgrades for golden Cookies, so i can gain the bonuses from a frenzy + lucky or frenzy + clicking frenzy or frenzy + elder frenzy combo. Theoretically, it is best to click all cookies, red and golden, always, because the income of all cookies is added to your "total baked cookies", while the negative from "ruin" is NOT withdrawn from this total! However, in midgame there are situations where you dont want to click a red cookie: While you are building up your frenzy+lucky stack. The worst that can happen here is getting frenzy+ruin, because the *7 from "frenzy" applies to "ruin" as well as to "lucky". Wait until you have your wrinklers, then take a look at your Cps: you will want a bank/stack of Your Cps * 2 * 7 * 12000 (the *2 because of the -50% from 10 Wrinklers, skip the *2 it if u dont have Wrinklers), PLUS a bonus of ~10% of that value in case u get a "frenzy/ruin" in later gameplay.
For the start, "Christmas season" is the best starting season, for it provides the Reindeer, which can be used in a combo of frenzy+elder frenzy+reindeer (does not work with "clicking frenzy", for this bonus only applies to your clicks on the big cookie). For this, u have to let the reindeer appear shortly after a golden/red cookie. This is done by either waiting for the reindeer to jump far to the right screen side and clicking red/gold cookies fast, or by waiting during the existence of a gold/red cookie and clicking it as late as possible before the reindeer appears. Whenever u had this combo, u can switch to a season where u dont have all bonuses yet (easter / halloween) to pop the wrinklers, then switch back to christmas (care, the price for switching rises fast).
For we are talking about midgame, keep in mind that there are several upgrades that are more important than getting the next prisma: These are the "twice efficiency" upgrades for prisma and the kittens, which all about double your CPs every time. If u have lets say 30 prismas and could buy 10 more or could buy a kitten or a "twice effi" for prismas, go for the kittens/effi upgrades, for they will work like u have over 60 prismas at that time compared to before :D. Sometimes you cannot see an upgrade yet, because you do not yet have enough of the buildings needed in order to unlock the upgrade, so keep in mind at how many buildings your upgrades unlock.
After every upgrade / building u bought, recalculate your Cps*2*7*12 to see your new optimum stack/bank size. Reach this first before buying any further upgrades / buildings, so u get your maximum out of a frenzy/lucky combo. This is, after a frenzy / Elder frenzy and frenzy / clicking frenzy your main income source!
Other buildings than prisma: You might have already seen that other buildings than prisma are really uneffective, compared to Prisms. I simply level them by letting the value of the next building to buy be 90% less the next higher valued building. For example, if my next prism costs 100 T, then my next Antimatter costs 10T, my next Time machine costs 1 T, my next Portal costs 100 B and so on, except for Grandmas and Cursors, which do produce much better than other buildings. I think, leaving both of these at 1% of your next prism is fair. (This rule would apply after reachin 100 buildings of a type, because it s a bit unstable below because of the various upgrades)
I usually reset my game only if i can double my Heavenly chips by this, because this will mean double speed in the next try. Maybe i m wrong here and change this way of thinking if u have a good argument? :D
Hope u liked my small guide, c ya around ;)