With 10 wrinklers active during Frenzy your entire income is multiplied by 42.
Meaning if you have 1 billion cps it would now be 42 billion cps.
You get x7 from the Frenzy and the 10 wrinklers give x6. The wrinklers eat all the Frenzied cookies, meaning they stack togethor, making it 6x7 = 42.
The only thing that beats this is Elder Frenzy with 10 Wrinkers which give an outrageous 3,996 * income (Ex. 1 billion cps = 3.996 trillion cps).
I'm not if it's possible (I can't see why not) but if you happen to get a Cookie Frenzy, then the next bonus cookie was an elder frenzy, then with 10 wrinklers active your income would be multiplied by 27,972 (Ex. 1 billion cps = 27.972 trillion cps). I have never had this occur so I don't know if the Elder Frenzy would stop the Cookie Frenzy since one is a golden cookie and the other is a wrath.